Cocaine overdose is a serious risk in Australia, potentially leading to severe side effects or death. This article discusses the signs of overdose, associated risks, and emergency response actions.

When most people think about drugs they usually consider substances like heroin, cocaine and cannabis. These substances have been around for a long time, and most people have an idea of their effects.
But in the past few decades, illicit manufacturers have begun producing a range of novel drugs. These drugs come with their own effects and risks.
In this blog, we explore what they are, what they do, and how you can get help if you become addicted to one of these substances.
Novel synthetic drugs are narcotics which have only recently started being manufactured. The reason for their creation tends to fall into one of two categories – the first is that they mimic the effects of a similar drug while also being legal, like synthetic cathinones around 2010 before they were banned in much of the world.
The second category of synthetic drugs is those which are manufactured because they are more potent and less expensive than traditional drugs, meaning greater profits for producers and distributors. Fentanyl is an example of this. Illicit manufacturers started producing fentanyl in great quantities in China in the 1990s and it is now used more widely than heroin.
While heroin must be cultivated from opium poppies, the process for fentanyl is entirely synthetic, meaning that it can be manufactured entirely in a laboratory.
In many countries, regulators play “whack a mole” with these synthetic drugs, as whenever one is banned, manufacturers change the chemical formula slightly, creating another drug which regulators must then criminalise.
This is not the case in Australia, where blanket bans on possessing or selling substances that have a psychoactive effect are in place in most jurisdictions. Commonwealth laws also ban substances with psychoactive effects that are not otherwise covered by existing legislation.
These are the most commonly found synthetic drugs in Australia. All of these substances can cause significant harm and addiction.
These drugs mimic the effects of THC, which is one of the active ingredients in cannabis. These products tend to contain the chemical JWH-018, but other synthetic cannabinoids including JWH-073; JWH-200; JWH-250; AM-2201, RCS-4 and SCP 47,497 may be found in synthetic cannabinoid products.
Typically these chemicals are sprayed on plant matter which looks somewhat similar to cannabis. These synthetic drugs in Australia can cause addiction and immense harm. While the chemicals in cannabis only partially bind to cb1r AND CB2r receptors, synthetic cannabinoids are full agonists, which may explain the extreme side effects reported by some people.
The most common street name for these substances is “spice”. Spice is now one of the more popular drugs in prisons in Australia, and it is common for inmates to become hooked while they are serving their sentences.
These are opioids which mimic the effects of opioids such as heroin. While heroin is itself a very dangerous substance, synthetic opioids can kill in much smaller quantities. The LD50 (amount that kills 50% of the population) of fentanyl is only 2 to 3 milligrams when administered intravenously.
Fentanyl and similar opioids are the reason for the enormous rise in overdose deaths in countries like the United States and Canada in recent years. Fortunately, novel synthetic opioids are not commonly found in Australia, and so overdose rates remain much lower than in some other countries.
Many synthetic opioids, such as carfentanil, are closely related to fentanyl, sharing a similar chemical composition. These opioids usually have a similar level of potency as fentanyl.
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